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Exalpha

Gi alpha 1/2 Polyclonal Antibody

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Product Details

X1595P

Applications
Tested Dilution
Publications

Western Blot (WB)

5-10 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide corresponding to amino acids 345-354 of Gi 1 and 346-355 of Gi 2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-2 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

PBS

Contains

0.08% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: IMR-5 cells or brain.

Target Information

The G protein family of signal transducers includes the alpha, beta, gamma subunits and the effector which are most clearly distinguished by their different alpha chains. The family also includes Gs and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein of unknown function that is abundantly expressed in brain; and transducin 1 and 2, proteins involved in retinal phototransduction. The G proteins possess GTPase activity and are components of a complex membrane signaling system that includes membrane-bound receptors. The system exists to modulate extracellular signals as they are transmitted into the cell.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Adenylate cyclase-inhibiting G alpha protein; G alpha inhibitory type 2 (a); G alpha inhibitory type 2 (b); G protein; Gi1 protein alpha subunit; GNAI2; GTP-binding protein (G-alpha-i2); GTP-binding regulatory protein Gi alpha-2 chain; guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein (G protein), alpha inhibiting 1; guanine nucleotide binding protein (G protein), alpha inhibiting 2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; guanine nucleotide binding protein, alpha inhibiting 1; guanine nucleotide binding protein, alpha inhibiting 2; guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2; guanine nucleotide-binding protein alpha-i subunit; Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-1 subunit; guanine nucleotide-binding protein G(i), alpha-2 subunit; guanine nucleotide-binding regulatory protein alpha-inhibitory subunit; heterotrimeric guanine nucleotide-binding protein 1B; heterotrimeric guanine nucleotide-binding protein 1C; p-alpha-h subunit; sGi2; unnamed protein product

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Gene Aliases: AU046200; BPGTPB; C76432; Galphai2; Gi; Gia; Gialpha1; GIP; Gnai-1; Gnai-2; GNAI1; GNAI2; GNAI2B; H_LUCA15.1; H_LUCA16.1; HG1B; HG1C; NEDHISB

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UniProt ID: (Bovine) P63097, (Human) P63096, (Human) P04899, (Rat) P10824, (Mouse) B2RSH2, (Rat) P04897, (Mouse) P08752

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Entrez Gene ID: (Bovine) 281790, (Human) 2770, (Human) 2771, (Bovine) 281791, (Rat) 25686, (Mouse) 14677, (Rat) 81664, (Mouse) 14678

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Function(s)
magnesium ion binding G-protein coupled receptor binding GTPase activity protein binding GTP binding GDP binding nucleotide binding obsolete small monomeric GTPase activity adenylate cyclase regulator activity adenylate cyclase inhibitor activity hydrolase activity guanyl nucleotide binding G-protein beta/gamma-subunit complex binding D2 dopamine receptor binding G-protein coupled serotonin receptor binding metal ion binding signal transducer activity GTPase activating protein binding heterotrimeric G-protein
Process(es)
cell cycle G-protein coupled receptor signaling pathway regulation of cAMP-mediated signaling cell division regulation of mitotic spindle organization cellular response to forskolin positive regulation of protein localization to cell cortex signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting serotonin receptor signaling pathway neuropeptide signaling pathway response to prostaglandin E response to peptide hormone positive regulation of cholesterol biosynthetic process negative regulation of insulin secretion chemokine-mediated signaling pathway T cell migration positive regulation of relaxation of smooth muscle adenosine receptor signaling pathway negative regulation of adenylate cyclase activity G-protein coupled acetylcholine receptor signaling pathway gamma-aminobutyric acid signaling pathway response to nutrient cell proliferation positive regulation of cell proliferation positive regulation of cell migration positive regulation of superoxide anion generation positive regulation of urine volume negative regulation of calcium ion-dependent exocytosis modulation of synaptic transmission negative regulation of synaptic transmission regulation of calcium ion transport positive regulation of ERK1 and ERK2 cascade negative regulation of adrenergic receptor signaling pathway positive regulation of vascular smooth muscle cell proliferation positive regulation of neural precursor cell proliferation negative regulation of apoptotic signaling pathway metabolic process activation of MAPKK activity G-protein coupled glutamate receptor signaling pathway regulation of heart contraction intracellular signal transduction
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