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This antibody is predicted to react with chicken, mouse and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is brain tissue.
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AMPA 1; AMPA-selective glutamate receptor 1; GluA1; GluR-1; GluR-A; GluR-K1; Glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, metabotropic 1; GPRC1A; GRM1A; Metabotropic glutamate receptor 1; mGlu1; MGLUR1; MGLUR1A; protein phosphatase 1, regulatory subunit 85
Gene Aliases: GluA1; GLUH1; GLUR1; GLURA; GPRC1A; GRIA1; GRM1; HBGR1; MGLU1; MGLUR1; PPP1R85; SCAR13
UniProt ID: (Human) P42261, (Human) Q13255
Entrez Gene ID: (Human) 2890, (Human) 2911
Molecular Function:
ion channel
ionotropic glutamate receptor
ligand-gated ion channel
receptor
transporter
G-protein coupled receptor
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