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Invitrogen
GluR1 Polyclonal Antibody
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Product Details
PA5-32425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide from C-terminus of human GluR1.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.6, with 1% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with chicken, mouse and rat based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is brain tissue.
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AI853806; AMPA 1; AMPA receptor subunit GluA1; AMPA-selective glutamate receptor 1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluRK1; glutamate receptor; Glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; NR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1; unnamed protein product
Gene Aliases: GLUA1; GLUH1; GLUR1; GLURA; GRIA1; HBGR1; MRD67; MRT76
UniProt ID: (Human) P42261
Entrez Gene ID: (Human) 2890
beta-amyloid binding
G-protein alpha-subunit binding
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
ion channel activity
protein binding
adenylate cyclase binding
ligand-gated ion channel activity
immunoglobulin binding
protein kinase binding
protein domain specific binding
glutamate-gated calcium ion channel activity
PDZ domain binding
small GTPase binding
myosin V binding
G-protein beta-subunit binding
beta-2 adrenergic receptor binding
glutamate receptor binding
signaling receptor activity
identical protein binding
protein kinase A binding
peptide hormone receptor binding
scaffold protein binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
regulation of receptor recycling
ion transport
signal transduction
chemical synaptic transmission
synapse assembly
long-term memory
response to xenobiotic stimulus
response to toxic substance
response to sucrose
response to lithium ion
positive regulation of gene expression
neuronal action potential
calcium-mediated signaling
spinal cord development
cerebral cortex development
receptor internalization
response to nutrient levels
response to estradiol
ion transmembrane transport
regulation of ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
response to cocaine
response to morphine
response to peptide hormone
response to ethanol
positive regulation of membrane potential
response to arsenic-containing substance
regulation of synaptic plasticity
behavioral response to pain
modulation of synaptic transmission
positive regulation of synaptic transmission
response to electrical stimulus
regulation of postsynaptic membrane potential
long-term synaptic potentiation
long term synaptic depression
response to fungicide
cellular response to amino acid stimulus
cellular response to ammonium ion
cellular response to dsRNA
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to amine stimulus
positive regulation of locomotion involved in locomotory behavior
regulation of presynaptic membrane potential
cellular response to L-glutamate
cellular response to brain-derived neurotrophic factor stimulus
conditioned place preference
response to psychosocial stress
positive regulation of excitatory postsynaptic potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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