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Glucocorticoid Receptor beta Polyclonal Antibody

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Glucocorticoid Receptor beta Polyclonal Antibody

Product Details

BS-13385R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-500
-

Immunocytochemistry (ICC/IF)

1:100-500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Glucocorticoid Receptor beta
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.03% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism, and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocorticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that the alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform has been observed to translocate from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR beta might function as a dominant negative inhibitor of GR alpha activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Glucocorticoid receptor; glucocorticoid receptor 1; GR; GR Beta; hGR DL-1; hGR NS-1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3 group C member 1 variant hGR-B(54); nuclear receptor subfamily 3 group C member 1 variant hGR-B(77); nuclear receptor subfamily 3 group C member 1 variant hGR-B(93); nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); putative upstream ORF.; Unknown; unnamed protein product

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Gene Aliases: GCCR; GCR; GCRST; GR; GRL; Grl-1; Grl1; NR3C1

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UniProt ID: (Human) P04150, (Mouse) P06537, (Rat) P06536

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Entrez Gene ID: (Human) 2908, (Mouse) 14815, (Rat) 24413

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding glucocorticoid receptor activity steroid binding protein binding zinc ion binding lipid binding TBP-class protein binding protein kinase binding estrogen response element binding identical protein binding sequence-specific DNA binding metal ion binding Hsp90 protein binding steroid hormone binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding steroid hormone receptor activity transcription coactivator activity transcription factor binding Hsp70 protein binding receptor tyrosine kinase binding heat shock protein binding protein complex binding glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity hormone binding protein homodimerization activity protein heterodimerization activity protein dimerization activity
Process(es)
regulation of gluconeogenesis chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter glucocorticoid metabolic process regulation of glucose metabolic process positive regulation of glutamate secretion chromatin modification adrenal gland development negative regulation of synaptic plasticity regulation of glucocorticoid biosynthetic process regulation of cell proliferation maternal behavior glucocorticoid receptor signaling pathway negative regulation of vascular permeability steroid hormone mediated signaling pathway glucocorticoid mediated signaling pathway positive regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter response to arsenic-containing substance chromatin-mediated maintenance of transcription mammary gland duct morphogenesis positive regulation of dendritic spine development positive regulation of cell growth involved in cardiac muscle cell development cellular response to steroid hormone stimulus cellular response to dexamethasone stimulus negative regulation of glucocorticoid mediated signaling pathway positive regulation of glucocorticoid receptor signaling pathway negative regulation of transcription from RNA polymerase II promoter chromatin organization regulation of transcription from RNA polymerase II promoter apoptotic process chromosome segregation signal transduction response to wounding gene expression microglia differentiation intracellular steroid hormone receptor signaling pathway nuclear receptor-mediated corticosteroid signaling pathway synaptic transmission, glutamatergic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated astrocyte differentiation cell division response to glucocorticoid response to cortisol motor behavior cellular response to glucocorticoid stimulus cellular response to transforming growth factor beta stimulus neuroinflammatory response response to ketone positive regulation of pri-miRNA transcription from RNA polymerase II promoter brain development aging circadian rhythm androgen metabolic process response to radiation response to activity response to inactivity muscle atrophy lung development response to insulin response to mercury ion response to corticosterone response to calcium ion response to electrical stimulus cellular response to magnesium ion response to dexamethasone
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