PA1-121 detects gonadotropin releasing hormone (GnRH) in mouse brain and in amphibian (Hyla cinerea) samples.
PA1-121 has been successfully used in immunohistochemistry procedures. Immunohistochemical staining of GnRH in mouse embryo brain tissue using PA1-121 results in staining of neurons in the organum vasculosum of the lamina terminalis (OVLT).
In immunohistochemical procedures, 4% paraformaldehyde is recommended as a fixative.
The PA1-121 immunogen is a synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH. This sequence is completely conserved in rat and tree shrew and is 78% conserved in zebrafish. The PA1-121 immunizing peptide (Cat. # PEP-168) is available for use in neutralization and control experiments.
The Luteinizing Hormone Releasing Hormone (LH-RH) is produced in the hypothalamus and influences the release of Luteinizing Hormone in the pituitary gland. LH-RH is also known as Gonadotropin-releasing hormone (Gn-RH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GnRH-I; Gonadoliberin I; Gonadoliberin-1; gonadotropin releasing hormone 2; Gonadotropin-releasing hormone I; hypogonadal; LH-RH I; Luliberin I; luteinizing hormone releasing hormone; Luteinizing hormone-releasing hormone I; Lutropin; Progonadoliberin I; Progonadoliberin-1; Prolactin release-inhibiting factor 1; Prolactin release-inhibiting factor I
Gene Aliases: Gnrh; Gnrh1; Gnrh2; hpg; LHRH; Lhrh1; Lnrh
UniProt ID: (Mouse) P13562
Entrez Gene ID: (Mouse) 14714