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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:50 - 1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-262 of human GZMA. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.42 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2808341 |
Immunogen sequence: IIGGNEVTPH SRPYMVLLSL DRKTICAGAL IAKDWVLTAA HCNLNKRSQV ILGAHSITRE EPTKQIMLVK KEFPYPCYDP ATREGDLKLL QLTEKAKINK YVTILHLPKK GDDVKPGTMC QVAGWGRTHN SASWSDTLRE VNITIIDRKV CNDRNHYNFN PVIGMNMVCA GSLRGGRDSC NGDSGSPLLC EGVFRGVTSF GLENKCGDPR GPGVYILLSK KHLNWIIMTI KGAV; Positive Samples: Mouse spleen, Mouse thymus, Rat intestine, Rat spleen; Cellular Location: Cytoplasmic granule
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Autocrine thymic lymphoma granzyme-like serine protease; BLT esterase; CTL tryptase; CTLA-3; Cytotoxic T-lymphocyte proteinase 1; Cytotoxic T-lymphocyte-associated serine esterase-3; Fragmentin-1; granzyme 1; Granzyme A; Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease); granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); Granzyme-1; H factor; Hanukah factor; Hanukah factor serine protease); Hanukkah factor; HF; serine esterase 1; T cell-specific serine protease 1; TSP-1
Gene Aliases: AW494114; Ctla-3; CTLA3; GZMA; Hf; HFSP; Mtsp-1; SE1; TSP-1; TSP1
UniProt ID: (Human) P12544, (Mouse) P11032
Entrez Gene ID: (Human) 3001, (Rat) 266708, (Mouse) 14938
Molecular Function:
protease
serine protease
protein modifying enzyme
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