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Growth Hormone Polyclonal Antibody

View all (54) Growth Hormone antibodies

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Growth Hormone Polyclonal Antibody

Product Details

GH-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:5,000-1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

N-epitope synthetic peptide taken within amino acid region 1-60 on human Growth Hormone beta subunit protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The GH1 gene, along with 4 additional related genes, is located at the growth hormone locus on chromosome 17. The five genes share a remarkably high degree of sequence identity. Alternative splicing results in 5 isoforms ranging from approximately 19 kDa to 24 kDa. HGH is produced by the somatotroph cells in the pituitary. It acts through binding to membrane receptors that belong to the cytokine receptor subfamily. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Mutations or deletions in the gene lead to growth hormone deficiency and short stature.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GH; GH1; Growth hormone; Growth hormone 1; growth hormone B5; HGH; Pituitary growth hormone; rHGH; Somatotropin; unnamed protein product

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Gene Aliases: GH; GH-N; GH1; GHB5; GHN; hGH-N; IGHD1A; IGHD1B; IGHD2; RNGHGP

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UniProt ID: (Human) P01241, (Mouse) P06880, (Rat) P01244

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Entrez Gene ID: (Human) 2688, (Mouse) 14599, (Rat) 24391

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Function(s)
cytokine activity growth hormone receptor binding prolactin receptor binding hormone activity protein binding growth factor activity metal ion binding growth hormone activity peptide hormone
Process(es)
positive regulation of receptor internalization JAK-STAT cascade positive regulation of glucose transport cytokine-mediated signaling pathway response to nutrient levels response to estradiol positive regulation of multicellular organism growth proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of JAK-STAT cascade animal organ development positive regulation of protein kinase B signaling growth hormone receptor signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway negative regulation of growth hormone receptor signaling pathway bone maturation receptor signaling pathway via STAT neuroblast proliferation response to light stimulus glucose transport response to food cellular response to insulin stimulus regulation of intracellular steroid hormone receptor signaling pathway positive regulation of growth lung alveolus development positive regulation of neurogenesis positive regulation of steroid hormone biosynthetic process negative regulation of neuron death signal transduction female pregnancy response to cytokine regulation of growth response to peptide hormone positive regulation of cell differentiation
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