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Invitrogen
H-Ras Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-87037
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide of human HRAS.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogene coding for closely related Ras proteins: H-, K-, N-Ras. Oncogenic mutations in Ras genes are present in ~30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibition of apoptosis. K-Ras mutations are common in pancreatic, colorectal and nonsmall-cell lung carcinomas; H-Ras mutations are common in bladder, kidney and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies and hepatocellular carcinaoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; GTPase HRas; GTPase Hras1; H-ras 1 protein; H-Ras-1; Ha-Ras; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene 1; p21ras; Transforming protein p21
Gene Aliases: c-H-ras; c-Ha-ras; c-rasHa; H-ras; Ha-ras; Harvey-ras; HRAS; Hras-1; HRAS1; Kras2; ras
UniProt ID: (Mouse) Q61411, (Rat) P20171
Entrez Gene ID: (Mouse) 15461, (Rat) 293621
positive regulation of protein phosphorylation
endocytosis
apoptotic process
cell cycle arrest
mitotic cell cycle checkpoint
signal transduction
small GTPase mediated signal transduction
Ras protein signal transduction
cell aging
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
negative regulation of GTPase activity
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
positive regulation of Ras protein signal transduction
regulation of long-term neuronal synaptic plasticity
positive regulation of epithelial cell proliferation
protein heterooligomerization
positive regulation of ERK1 and ERK2 cascade
positive regulation of wound healing
cellular senescence
intrinsic apoptotic signaling pathway
positive regulation of ruffle assembly
positive regulation of actin cytoskeleton reorganization
positive regulation of miRNA metabolic process
visual learning
actin cytoskeleton organization
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
social behavior
negative regulation of cell differentiation
striated muscle cell differentiation
epithelial tube branching involved in lung morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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