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Invitrogen

H-Ras Polyclonal Antibody

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H-Ras Polyclonal Antibody

Product Details

PA5-96852

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HRAS (NP_2035241)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808654

Product Specific Information

Positive Samples: SKOV3, Mouse brain, Mouse skeletal muscle, Mouse kidney, Rat brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus, Golgi apparatus membrane, Lipid-anchor, Lipid-anchor, Nucleus, perinuclear region

Immunogen sequence: MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI

Target Information

Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogene coding for closely related Ras proteins: H-, K-, N-Ras. Oncogenic mutations in Ras genes are present in ~30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibition of apoptosis. K-Ras mutations are common in pancreatic, colorectal and nonsmall-cell lung carcinomas; H-Ras mutations are common in bladder, kidney and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies and hepatocellular carcinaoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; GTP- and GDP-binding peptide B; GTPase HRas; GTPase Hras1; H-ras 1 protein; H-Ras-1; Ha-Ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene 1; HRAS; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; small GTP binding protein; transformation gene: oncogene HAMSV; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog

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Gene Aliases: C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; c-rasHa; CTLO; H-ras; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; HRAS; Hras-1; HRAS1; Kras2; p21ras; ras; RASH1

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UniProt ID: (Human) P01112, (Mouse) Q61411, (Rat) P20171

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Entrez Gene ID: (Human) 3265, (Mouse) 15461, (Rat) 293621

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Function(s)
nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity GDP binding protein anchor phospholipase C activator activity protein C-terminus binding small GTPase
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter endocytosis chemotaxis signal transduction cell surface receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis positive regulation of gene expression negative regulation of gene expression Schwann cell development positive regulation of cell migration positive regulation of interferon-gamma production regulation of actin cytoskeleton organization T-helper 1 type immune response regulation of cell proliferation myelination defense response to protozoan positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation T cell receptor signaling pathway neuron apoptotic process regulation of cell cycle adipose tissue development positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence oncogene-induced cell senescence intrinsic apoptotic signaling pathway regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of ruffle assembly positive regulation of miRNA metabolic process positive regulation of protein phosphorylation apoptotic process cell cycle arrest mitotic cell cycle checkpoint cell aging cell proliferation negative regulation of GTPase activity positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of DNA replication positive regulation of Ras protein signal transduction protein heterooligomerization positive regulation of actin cytoskeleton reorganization visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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