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Abnova
CYLD Monoclonal Antibody (2C3)
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Product Details
H00001540-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2C3
Immunogen
CYLD (AAH12342, 854 a.a. approximately 953 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: QNMELFAVLC IETSHYVAFV KYGKDDSAWL FFDSMADRDG GQNGFNIPQV TPCPEVGEYL KMSLEDLHSL DSRRIQGCAR RLLCDAYMCM YQSPTMSLYK
Target Information
CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyld; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; unnamed protein product
Gene Aliases: BRSS; CDMT; CYLD; CYLD1; CYLDI; EAC; FTDALS8; HSPC057; KIAA0849; MFT; MFT1; SBS; TEM; USPL2
UniProt ID: (Human) Q9NQC7
Entrez Gene ID: (Human) 1540
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
zinc ion binding
hydrolase activity
protein kinase binding
metal ion binding
Lys63-specific deubiquitinase activity
ubiquitinyl hydrolase activity, acting on linear ubiquitin
proline-rich region binding
Lys48-specific deubiquitinase activity
immune system process
proteolysis
I-kappaB kinase/NF-kappaB signaling
regulation of mitotic cell cycle
regulation of tumor necrosis factor-mediated signaling pathway
Wnt signaling pathway
protein deubiquitination
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
innate immune response
regulation of B cell differentiation
positive regulation of T cell differentiation
negative regulation of JNK cascade
homeostasis of number of cells
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of T cell receptor signaling pathway
regulation of necroptotic process
necroptotic process
regulation of microtubule cytoskeleton organization
protein K63-linked deubiquitination
negative regulation of canonical Wnt signaling pathway
ripoptosome assembly involved in necroptotic process
negative regulation of NIK/NF-kappaB signaling
regulation of cilium assembly
negative regulation of p38MAPK cascade
positive regulation of cellular protein localization
protein linear deubiquitination
negative regulation of interleukin-18-mediated signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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