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Abnova
NR4A2 Monoclonal Antibody (2G9)
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Product Details
H00004929-M18
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
2G9
Immunogen
NR4A2 (NP_006177, 147 a.a. approximately 250 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: GSLHNFHQNY VATTHMIEQR KTPVSRLSLF SFKQSPPGTP VSSCQMRFDG PLHVPMNPEP AGSHHVVDGQ TFAVPNPIRK PASMGFPGLQ IGHASQLLDT QVPS*
Target Information
The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HZF3; Immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B; NGFI-B beta; NGFI-B/nur77 beta-type transcription factor homolog; NOT; nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; putative new variant; T-cell nuclear receptor NOT; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor; unnamed protein product
Gene Aliases: HZF-3; IDLDP; NOT; NR4A2; NURR1; RNR1; TINUR
UniProt ID: (Human) P43354
Entrez Gene ID: (Human) 4929
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
zinc ion binding
glucocorticoid receptor binding
sequence-specific DNA binding
metal ion binding
retinoid X receptor binding
protein heterodimerization activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
neuron migration
response to amphetamine
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
nervous system development
adult locomotory behavior
post-embryonic development
gene expression
regulation of gene expression
central nervous system projection neuron axonogenesis
central nervous system neuron differentiation
habenula development
intracellular receptor signaling pathway
cellular response to oxidative stress
regulation of dopamine metabolic process
dopamine biosynthetic process
dopamine metabolic process
neuron maturation
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neuron apoptotic process
general adaptation syndrome
canonical Wnt signaling pathway
cellular response to corticotropin-releasing hormone stimulus
dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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