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Abnova
SHOX2 Monoclonal Antibody (1D1)
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Product Details
H00006474-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1D1
Immunogen
SHOX2 (NP_006875, 117 a.a. approximately 204 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: SPELKDRKDD AKGMEDEGQT KIKQRRSRTN FTLEQLNELE RLFDETHYPD AFMREELSQR LGLSEARVQV WFQNRRAKCR KQENQLHK
Target Information
SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein Og12X; OG-12; OGI2X; Paired family homeodomain protein Prx3; Paired-related homeobox protein SHOT; short stature homeobox 2; Short stature homeobox protein 2; SHOX homologous gene on chromosome 3; unnamed protein product
Gene Aliases: 6330543G17Rik; OG12; OG12X; Prx3; SHOT; SHOX2
UniProt ID: (Human) O60902, (Mouse) P70390, (Rat) O35750
Entrez Gene ID: (Human) 6474, (Mouse) 20429, (Rat) 25546
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
regulation of heart rate
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
chondrocyte development
sinoatrial node development
heart valve development
sinoatrial valve development
cardiac atrium morphogenesis
cardiac right atrium morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
nervous system development
mesenchymal cell proliferation
embryonic limb morphogenesis
regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
positive regulation of smoothened signaling pathway
embryonic digestive tract morphogenesis
embryonic morphogenesis
positive regulation of skeletal muscle fiber development
positive regulation of axonogenesis
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
muscle tissue morphogenesis
cardiac pacemaker cell differentiation
sinoatrial node cell development
stem cell proliferation
regulation of branching morphogenesis of a nerve
positive regulation of stem cell proliferation
multicellular organism development
positive regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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