Search
Abnova
IL21 Polyclonal Antibody, MaxPab™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
IL21 Antibody (H00059067-B01P) in WB
Western Blot analysis of IL21 expression in transfected 293T cell line (H00059067-T01) by IL21 MaxPab polyclonal antibody.
Lane 1: IL21 transfected lysate(17.82 KDa).
Lane 2: Non-transfected lysate.
Lane 1: IL21 transfected lysate(17.82 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00059067-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IL21 (NP_068575, 1 a.a. approximately 162 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MRSSPGNMER IVICLMVIFL GTLVHKSSSQ GQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
Target Information
IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CX2; four helix bundle cytokine; il 21; IL-21; ILN; Interleukin; Interleukin-21; Interleukin21; Za11
Gene Aliases: CVID11; IL-21; IL21; Za11
UniProt ID: (Human) Q9HBE4
Entrez Gene ID: (Human) 59067
natural killer cell differentiation
positive regulation of cytokine production
germinal center B cell differentiation
positive regulation of immunoglobulin production
positive regulation of natural killer cell cytokine production
immune response
signal transduction
tyrosine phosphorylation of STAT protein
positive regulation of cell proliferation
response to virus
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-17 production
positive regulation of natural killer cell differentiation
positive regulation of tissue remodeling
positive regulation of T cell proliferation
natural killer cell mediated cytotoxicity
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of natural killer cell mediated cytotoxicity
cell development
cell maturation
positive regulation of inflammatory response
positive regulation of lymphocyte activation
defense response to virus
T follicular helper cell differentiation
defense response to other organism
cellular response to virus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support