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Proteintech
HAAO Polyclonal Antibody
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Product Details
12791-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HAAO Fusion Protein Ag3511 (1-286 aa encoded by BC029510)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERRLGVRA WVKENRGSFQ PPVCNKLMHQ EQLKVMFIGG PNTRKDYHIE EGEEVFYQLE GDMVLRVLEQ GKHRDVVIRQ GEIFLLPARV PHSPQRFANT VGLVVERRRL ETELDGLRYY VGDTMDVLFE KWFYCKDLGT QLAPIIQEFF SSEQYRTGKP IPDQLLKEPP FPLSTRSIME PMSLDAWLDS HHRELQAGTP LSLFGDTYET QVIAYGQGSS EGLRQNVDVW LWQLEGSSVV TMGGRRLSLA PDDSLLVLAG TSYAWERTQG SVALSVTQDP ACKKPLG (1-286 aa encoded by BC029510)
Target Information
HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-HAO; 3-HAO {ECO:0000255|HAMAP-Rule:MF_03019}; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate 3,4-dioxygenase {ECO:0000255|HAMAP-Rule:MF_03019}; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilate oxygenase {ECO:0000255|HAMAP-Rule:MF_03019}; 3-hydroxyanthranilic acid dioxygenase; 3-hydroxyanthranilic acid dioxygenase {ECO:0000255|HAMAP-Rule:MF_03019}; HAAO; HAD; HAD {ECO:0000255|HAMAP-Rule:MF_03019}; unnamed protein product
Gene Aliases: 0610007K21Rik; 0610012J07Rik; 3-HAO; 3-HAOxase; 3HAO; h3HAO; HAAO; HAO; VCRL1
UniProt ID: (Human) P46952, (Mouse) Q78JT3, (Rat) P46953
Entrez Gene ID: (Human) 23498, (Mouse) 107766, (Rat) 56823
tryptophan catabolic process
NAD biosynthetic process
response to zinc ion
pyridine nucleotide biosynthetic process
quinolinate biosynthetic process
'de novo' NAD biosynthetic process from tryptophan
anthranilate metabolic process
dicarboxylic acid metabolic process
response to cadmium ion
quinolinate metabolic process
neuron cellular homeostasis
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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