Immunogen sequence: MKVEVLPALT DNYMYLVIDD ETKEAAIVDP VQPQKVVDAA RKHGVKLTTV LTTHHHWDHA GGNEKLVKLE SGLKVYGGDD RIGALTHKIT HLSTLQVGSL NVKCLATPCH TSGHICYFVS KPGGSEPPAV FTGDTLFVAG CGKFYEGTAD EMCKALLEVL GRLPPDTRVY CGHEYTINNL KFARHVEPGN AAIREKLAWA KEKYSIGEPT VPSTLAEEFT YNPFMRVREK TVQQHAGETD PVTTMRAVRR EKDQFKMPRD; Positive Samples: MCF7, HepG2, Mouse liver, Mouse kidney, Mouse heart, Rat liver, Rat kidney; Cellular Location: Cytoplasm, Mitochondrion matrix
The enzyme encoded by the HAGH gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. Diseases associated with HAGH include Hydroxyacyl Glutathione Hydrolase Deficiency.
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Protein Aliases: Glx II; Glyoxalase II; glyoxylase 2; Hydroxyacylglutathione hydrolase, mitochondrial; hydroxyacylglutathione hydroxylase; Round spermatid protein RSP29
Gene Aliases: BC019817; Glo-2; GLO2; GLX2; GLXII; HAGH; HAGH1; RSP29
Molecular Function: hydrolase