In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human HAI-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: FLJ45571; HAI-2; Hepatocyte growth factor activator inhibitor type 2; Kunitz-type protease inhibitor 2
Gene Aliases: AL024025; C76321; HAI-2; Hai2; Spint2
UniProt ID: (Mouse) Q9WU03
Entrez Gene ID: (Mouse) 20733