Peptide sequence: MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM
Sequence homology: Human: 100%; Rat: 83%
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HEPC; Hepc20; Hepc25; Hepcidin; Hepcidin antimicrobial peptide; Hepcidin-20; Hepcidin-25; HFE2B; LEAP-1; LEAP1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
Gene Aliases: HAMP; HEPC; HFE2B; LEAP1; PLTR; UNQ487/PRO1003