Immunogen sequence: MALSSQIWAA CLLLLLLLAS LTSGSVFPQQ TGQLAELQPQ DRAGARASWM PMFQRRRRRD THFPICIFCC GCCHRSKCGM CCKT; Positive Samples: MDA-MB-435
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
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Protein Aliases: Hepc20; Hepc25; Hepcidin; hepcidin antimicrobial peptide 1; Hepcidin-20; Hepcidin-25; LEAP-1; Liver-expressed antimicrobial peptide 1; PLTR; Putative liver tumor regressor
Gene Aliases: HAMP; Hamp1; HEPC; Hepc1; HFE2B; LEAP1; PLTR; UNQ487/PRO1003