For Western Blot, this antibody has non-specific bands at 50 kDa.
This antibody is predicted to react with mouse, rat, sheep, rabbit, chicken, cow and pig based on sequence homology.
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
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Protein Aliases: bHLHa27; Class A basic helix-loop-helix protein 27; eHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; Heart- and neural crest derivatives-expressed protein 1; Hxt, Thing1, bHLHa27, eHand, class A basic helix-loop-helix protein 27
Gene Aliases: BHLHA27; EHAND; HAND1; Hxt; Thing1
UniProt ID: (Human) O96004
Entrez Gene ID: (Human) 9421