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Invitrogen
HAND1 Polyclonal Antibody
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Product Details
PA5-67623
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human HAND1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HAND1 belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic helix-loop-helix protein; bHLHa27; Class A basic helix-loop-helix protein 27; eHAND; Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; Heart- and neural crest derivatives-expressed protein 1
Gene Aliases: BHLHA27; EHAND; HAND1; Hxt; Thing1
UniProt ID: (Human) O96004
Entrez Gene ID: (Human) 9421
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
identical protein binding
protein homodimerization activity
bHLH transcription factor binding
sequence-specific DNA binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
in utero embryonic development
mesoderm formation
blastocyst development
trophectodermal cell differentiation
heart looping
embryonic heart tube formation
cardiac left ventricle formation
cardiac right ventricle formation
regulation of transcription from RNA polymerase II promoter
heart development
cell differentiation
embryonic heart tube development
odontogenesis of dentin-containing tooth
positive regulation of transcription from RNA polymerase II promoter
ventricular cardiac muscle tissue morphogenesis
cardiac septum morphogenesis
mesenchyme development
cartilage morphogenesis
trophoblast giant cell differentiation
determination of heart left/right asymmetry
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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