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Proteintech
HAPLN4 Polyclonal Antibody
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Product Details
21228-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HAPLN4 Fusion Protein Ag15687 (30-206 aa encoded by BC142644)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Amount
81 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QRGRKKVVH VLEGESGSVV VQTAPGQVVS HRGGTIVLPC RYHYEAAAHG HDGVRLKWTK VVDPLAFTDV FVALGPQHRA FGSYRGRAEL QGDGPGDASL VLRNVTLQDY GRYECEVTNE LEDDAGMVKL DLEGVVFPYH PRGGRYKLTF AEAQRACAEQ DGILASAEQL HAAWRDGL (30-206 aa encoded by BC142644 )
Target Information
Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brain link protein 2; brain linked protein 2; Hyaluronan and proteoglycan link protein 4; link protein; link protein 4
Gene Aliases: 9330174O11; BRAL2; HAPLN4; KIAA1926; Lpr4
UniProt ID: (Human) Q86UW8, (Mouse) Q80WM4
Entrez Gene ID: (Human) 404037, (Mouse) 330790, (Rat) 361129
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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