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Product Details
11301-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HARS2 Fusion Protein Ag1827 (157-506 aa encoded by BC014982)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can bind both HARSs for the close sequences.
Immunogen sequence: WRRESPTIV QGRYREFCQC DFDIAGQFDP MIPDAECLKI MCEILSGLQL GDFLIKVNDR RIVDGMFAVC GVPESKFRAI CSSIDKLDKM AWKDVRHEMV VKKGLAPEVA DRIGDYVQCH GGVSLVEQMF QDPRLSQNKQ ALEGLGDLKL LFEYLTLFGI ADKISFDLSL ARGLDYYTGV IYEAVLLQTP TQAGEEPLNV GSVAAGGRYD GLVGMFDPKG HKVPCVGLSI GVERIFYIVE QRMKTKGEKV RTTETQVFVA TPQKNFLQER LKLIAELWDS GIKAEMLYKN NPKLLTQLHY CESTGIPLVV IIGEQELKEG VIKIRSVASR EEVAIKRENF VAEIQKRLSE S (157-506 aa encoded by BC014982)
Target Information
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 6.1.1.21; HARS-related; HisRS; histidine translase; histidine tRNA ligase 2, mitochondrial (putative); Histidine--tRNA ligase, mitochondrial; Histidine--tRNA ligase-like; histidine-tRNA ligase homolog; Histidyl-tRNA synthetase; histidyl-tRNA synthetase 2; histidyl-tRNA synthetase 2, mitochondrial (putative); probable histidine--tRNA ligase, mitochondrial; probable histidyl-tRNA synthetase, mitochondrial; zinc finger, matrin type 2
Gene Aliases: 4631412B19Rik; HARS2; Hars2l; HARSL; HARSR; HO3; PRLTS2; RGD1308426; Zmat2
UniProt ID: (Human) P49590, (Mouse) Q99KK9
Entrez Gene ID: (Human) 23438, (Rat) 307491, (Mouse) 70791
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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