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Proteintech
HAS3 Polyclonal Antibody
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Product Details
15609-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HAS3 Fusion Protein Ag7999 (1-281 aa encoded by BC021853)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPVQLTTAL RVVGTSLFAL AVLGGILAAY VTGYQFIHTE KHYLSFGLYG AILGLHLLIQ SLFAFLEHRR MRRAGQALKL PSPRRGSVAL CIAAYQEDPD YLRKCLRSAQ RISFPDLKVV MVVDGNRQED AYMLDIFHEV LGGTEQAGFF VWRSNFHEAG EGETEASLQE GMDRVRDVVR ASTFSCIMQK WGGKREVMYT AFKALGDSVD YIQVCDSDTV LDPACTIEML RVLEEDPQVG GVGGDVQPPG KGMAVEDDQV QAAQVRATEA WSVHQRHVSR EQ (1-281 aa encoded by BC021853)
Target Information
HAS1, HAS2 and HAS3 are HA (hyaluronan or hyaluronic acid) synthase proteins. The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by b-1,3 and b-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli, suggesting distinct functional roles of the three proteins. HAS3 produces both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. HAS3 gene expression plays a crucial role in the regulation of hyaluronan synthesis in the epidermis. Specifically, IFN-g markedly upregulates HAS3 mRNA, whereas TGFbeta downregulates HAS3 transcript levels. The human HAS3 gene maps to chromosome 16q22. 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HA synthase 3; Hyaluronan synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3
Gene Aliases: HAS3
UniProt ID: (Human) O00219, (Mouse) O08650
Entrez Gene ID: (Human) 3038, (Mouse) 15118, (Rat) 266805
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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