Immunogen sequence: TPFQGQGHGA QLLETVHRYY TEFPTVLDIT AEDPSKSYVK LRDFVLVKLC QDLPCFSREK LMQGFNEDMA IEAQQKFKIN KQHARRVYEI LRLLVTDMSD AEQYRSYRLD IKRRLISPYK KKQRDLAKMR KCLRPEELTN QMNQIEISMQ HEQLEESFQE LVEDYRRVIE RLAQE; Positive Samples: MCF7, SW480, Jurkat, 293T, HeLa, HepG2, U-251MG, Mouse spleen, Rat testis; Cellular Location: Cytoplasm, Nucleus, Nucleus matrix, nucleoplasm
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: histidine aminotransferase 1; Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit; histone aminotransferase 1
Gene Aliases: 2410071B14Rik; AA536933; Hat-1; HAT1; KAT1
Molecular Function: histone modifying enzyme