The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.
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Protein Aliases: Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit
Gene Aliases: HAT1; KAT1
UniProt ID: (Human) O14929
Entrez Gene ID: (Human) 8520
Molecular Function: histone modifying enzyme