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HAUSP Polyclonal Antibody
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Product Details
BS-4281R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HAUSP/USP7, amino acids 801-897.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
USP7 or HAUSP is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, HAUSP activity generally stabilizes its substrate proteins. HAUSP is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53. Normally, p53 levels are kept low in part due to Mdm2-mediated ubiquitylation and degradation of p53. Interestingly, in response to oncogenic insults, HAUSP can deubiquitinate p53 and protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another important role of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chromosome 16p13.2 deletion syndrome; Deubiquitinating enzyme 7; Herpes virus-associated ubiquitin-specific protease; herpes-virus-associated ubiquitin-specific protease; Herpesvirus-associated ubiquitin-specific protease; mHAUSP; rHAUSP; Ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7; ubiquitin specific protease 7 (herpes virus-associated); Ubiquitin thioesterase 7; ubiquitin thiolesterase 7; Ubiquitin-specific-processing protease 7; unnamed protein product; USP7; herpes virus-associated protease
Gene Aliases: 2210010O09Rik; AA409944; AA617399; AU019296; AW548146; C16DELp13.2; C80752; DEL16P13.2; HAFOUS; HAUSP; TEF1; USP7
UniProt ID: (Human) Q93009, (Rat) Q4VSI4, (Mouse) Q6A4J8
Entrez Gene ID: (Human) 7874, (Rat) 360471, (Mouse) 252870
p53 binding
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
ubiquitinyl hydrolase activity
Lys48-specific deubiquitinase activity
protein C-terminus binding
transcription factor binding
ubiquitin protein ligase binding
protein homodimerization activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
autophagosome assembly
DNA repair
transcription-coupled nucleotide-excision repair
DNA dealkylation involved in DNA repair
proteolysis
cellular response to DNA damage stimulus
negative regulation of autophagy
positive regulation of autophagy
protein ubiquitination
protein deubiquitination
regulation of protein stability
cellular response to nutrient levels
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
monoubiquitinated protein deubiquitination
TORC1 signaling
regulation of circadian rhythm
hypermethylation of CpG island
negative regulation of gluconeogenesis
rhythmic process
protein stabilization
regulation of sequence-specific DNA binding transcription factor activity
regulation of establishment of protein localization to telomere
symbiont-mediated disruption of host cell PML body
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
regulation of telomere capping
regulation of retrograde transport, endosome to Golgi
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
multicellular organism development
maintenance of DNA methylation
histone deubiquitination
negative regulation of NF-kappaB transcription factor activity
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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