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Proteintech
HAX1 Polyclonal Antibody
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Product Details
11266-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HAX1 Fusion Protein Ag1792 (1-279 aa encoded by BC014314)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSLFDLFRG FFGFPGPRSH RDPFFGGMTR DEDDDEEEEE EGGSWGRGNP RFHSPQHPPE EFGFGFSFSP GGGIRFHDNF GFDDLVRDFN SIFSDMGAWT LPSHPPELPG PESETPGERL REGQTLRDSM LKYPDSHQPR IFGGVLESDA RSESPQPAPD WGSQRPFHRF DDVWPMDPHP RTREDNDLDS QVSQEGLGPV LQPQPKSYFK SISVTKITKP DGIVEERRTV VDSEGRTETT VTRHEADSSP RGDPESPRPP ALDDAFSILD LFLGRWFRSR (1-279 aa encoded by BC014314)
Target Information
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ17042; FLJ18492; FLJ93803; HAX-1; HCLS1 (and PKD2) associated protein; HCLS1-associated protein X-1; HS1 binding protein; HS1-associated protein X-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1; OTTHUMP00000034190; RP11-137P24.1; unnamed protein product
Gene Aliases: HAX-1; HAX1; HCLSBP1; HS1BP1; HSP1BP-1; mHAX-1s; SCN3; SIG-111; Silg111
UniProt ID: (Human) O00165, (Mouse) O35387
Entrez Gene ID: (Human) 10456, (Mouse) 23897
mitochondrion organization
regulation of actin filament polymerization
positive regulation of granulocyte differentiation
granulocyte colony-stimulating factor signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
regulation of actin filament organization
regulation of mitophagy
regulation of protein targeting to mitochondrion
cell surface receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of actin cytoskeleton reorganization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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