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Invitrogen
HAX1a Polyclonal Antibody
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Product Details
PA5-20649
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the amino terminus of human Hax1a.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-20649 can be used with blocking peptide PEP-0769.
Target Information
The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HAX-1; HCLS1 (and PKD2) associated protein; HCLS1-associated protein X-1; HS1 binding protein; HS1-associated protein X-1; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1; RP11-137P24.1; unnamed protein product
Gene Aliases: HAX-1; HAX1; HCLSBP1; HS1BP1; HSP1BP-1; mHAX-1s; SCN3; SIG-111; Silg111
UniProt ID: (Human) O00165, (Rat) Q7TSE9, (Mouse) O35387
Entrez Gene ID: (Human) 10456, (Rat) 291202, (Mouse) 23897
mitochondrion organization
regulation of actin filament polymerization
positive regulation of granulocyte differentiation
granulocyte colony-stimulating factor signaling pathway
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
regulation of actin filament organization
regulation of mitophagy
regulation of protein targeting to mitochondrion
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of peptidyl-serine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of actin cytoskeleton reorganization
cell surface receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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