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Proteintech
HBP1 Polyclonal Antibody
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Product Details
11746-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HBP1 Fusion Protein Ag2342 (215-514 aa encoded by BC022329)
Conjugate
Form
Liquid
Concentration
0.09 mg/mL
Amount
13.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against the C-terminus of human HBP1.
Immunogen sequence: FLKGTRLCF HKGSNKEWQD VEDFARAEGC DNEEDLQMGI HKGYGSDGLK LLSHEESVSF GESVLKLTFD PGTVEDGLLT VECKLDHPFY VKNKGWSSFY PSLTVVQHGI PCCEVHIGDV CLPPGHPDAI NFDDPGVFDT FKSYDFTPMD SSAVYVLSSM ARQRRASLSC GGPGGQDFAR SGFSKNCGSP GSSQLSSNSL YAKAVKNHSS GTVSATSPNK CKRPMNAFML FAKKYRVEYT QMYPGKDNRA ISVILGDRWK KMKNEERRMY TLEAKALAEE QKRLNPDCWK RKRTNSGSQQ H (215-514 aa encoded by BC022329)
Target Information
The HMG-box protein-1 (HBP1) is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, that mediates DNA binding. HBP1 binds to the tumor suppressor proteins Rb and p130 and initiates cell cycle arrest. Terminal cell differentiation requires this initial cell cycle arrest followed by the coordinated expression of genes defined as tissue-specific markers. Along with initiating the commitment to cell differentiation, the continued activity of HBP1 abrogates the expression of tissue-specific genes by associating with the MyoD proteins. In muscle cell differentiation, the MyoD family of transcription factors, which include Myf5, MyoD and myogenein, induce the expression of these cell-type specific proteins and contribute to the development of cell phenotypes. The progression of terminal differentiation is, therefore, dependent on both a decrease in HBP1 activity and the corresponding activation of MyoD-induced gene transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: High mobility group box transcription factor 1; HMG box transcription factor 1; HMG box-containing protein 1; transcription factor; unnamed protein product
Gene Aliases: 1700058O05Rik; BE629963; C330012F01Rik; C86454; HBP1
UniProt ID: (Human) O60381, (Mouse) Q8R316
Entrez Gene ID: (Human) 26959, (Mouse) 73389
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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