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Product Details
10359-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HBS1L Fusion Protein Ag0388 (43-262 aa encoded by BC001465)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically recognizes the 75 kDa human HBS1L protein.
Immunogen sequence: SRRDKPSVE PVEEYDYEDL KESSNSVSNH QLSGFDQARL YSCLDHMREV LGDAVPDEIL IEAVLKNKFD VQKALSGVLE QDRVQSLKDK NEATVSTGKI AKGKPVDSQT SRSESEIVPK VAKMTVSGKK QTMGFEVPGV SSEENGHSFH TPQKGPPIED AIASSDVLET ASKSANPPHT IQASEEQSST PAPVKKSGKL RQQIDVKAEL EKRQGGKQLL N (43-262 aa encoded by BC001465)
Target Information
This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: eRF3 family member; ERF3-similar protein; ERFS; eukaryotic release factor 3; HBS1-like protein; HBS1-like translational GTPase; Hsp70 subfamily B suppressor 1-like protein
Gene Aliases: 2810035F15Rik; AI326327; EF-1a; eRF3c; ERFS; HBS1; HBS1L; HSPC276; KIAA1038
UniProt ID: (Human) Q9Y450, (Rat) Q6AXM7, (Mouse) Q69ZS7
Entrez Gene ID: (Human) 10767, (Rat) 293408, (Mouse) 56422
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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