|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 172 and 476 of Human HCC1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
PA5-31103 targets HCC1 in WB applications and shows reactivity with Human and mouse samples.
The PA5-31103 immunogen is recombinant fragment corresponding to a region within amino acids 172 and 476 of Human HCC1.
The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting.
PA5-31103 was used in western blot to study ATM-dependent responses to double-strand DNA breaks
|Kralovicova J,Knut M,Cross NC,Vorechovsky I||Scientific reports (6:null)||2016|