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Invitrogen
HCCS Polyclonal Antibody
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FIGURE: 1 / 2
HCCS Antibody (PA5-75378) in IHC (P)
Immunohistochemistry analysis of HCCS in paraffin-embedded human tonsil carcinoma tissue (secreted and membrane staining) and negative control (right, with PBS only). Samples were incubated with HCCS polyclonal antibody (Product # PA5-75378) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75378
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 80-120 of Human HCCS.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
CCHL (cytochrome c-type heme lyase), also known as HCCS (holocytochrome c-type synthase), is a 268 amino acid mitochondrial inner membrane protein that belongs to the cytochrome c-type heme lyase family. Containing two HRM (heme regulatory motif) repeats, HCCS participates in the covalent linkage of a heme group to an apoprotein of cytochrome c. The gene encoding HCCS maps to the human X chromosome. Defects to this gene cause microphthalmia syndromic type 7 (MCOPS7), also known as MIDAS syndrome or microphthalmia with linear skin defects (MLS). MCOPS7 is an X-linked male-lethal disorder that results in eye deformation, unilateral or bilateral microphthalmia, linear skin defects in affected females, and in utero lethality for males.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCHL; cytochrome c heme-lyase; Cytochrome c-type heme lyase; holocytochrome c synthase; holocytochrome c synthetase; Holocytochrome c-type synthase; microphthalamia with linear skin defects
Gene Aliases: CCHL; HCCS; LSDMCA1; MCOPS7; MLS; RGD1563855
UniProt ID: (Human) P53701, (Mouse) P53702
Entrez Gene ID: (Human) 3052, (Mouse) 15159, (Rat) 317444
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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