Immunogen sequence: IKLLDLKPYK VSWKADGTRY MMLIDGTNEV FMIDRDNSVF HVSNLEFPFR KDLRMHLSNT LLDGEMIIDR VNGQAVPRYL IYDIIKFNSQ PVGDCDFNVR LQCIEREIIS PRHEKMKTGL IDKTQEP
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GTase; GTP--RNA guanylyltransferase; HCAP1; HCE; MCE1; mRNA 5'-triphosphatase; mRNA guanylyltransferase; mRNA-capping enzyme; Polynucleotide 5'-triphosphatase; RP3-488C13.1; TPase
Gene Aliases: AU020997; CAP1A; hCAP; HCE; HCE1; MCE1; RNGTT
Molecular Function: mRNA capping factor