HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
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Protein Aliases: B cell/myeloid kinase; B-cell/myeloid kinase; BMK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK/p59-HCK; p59-HCK/p60-HCK; p59Hck; p61Hck; Tyrosine-protein kinase HCK
Gene Aliases: AI849071; Bmk; HCK; JTK9; p59Hck; p61Hck