|Tested species reactivity||Human|
|Host / Isotype||Rabbit|
|Immunogen||Synthetic peptide from human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1.|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:300-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN2. Interacts with KCNE2. Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.