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Invitrogen
HCN1 Polyclonal Antibody
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Product Details
PA5-53950
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HCN1. Recombinant protein control fragment (Product #RP-91018).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PSLPHEVSTL ISRPHPTVGE SLASIPQPVT AVPGTGLQAG GRSTVPQRVT LFRQMSSGAI PPNRGVPPAP PPPAAALPRE SSSVLNTDPD AE
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 87%.
Target Information
HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCNG-1; Brain cyclic nucleotide-gated channel 1; potassium channel; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Aliases: BCNG-1; BCNG1; DEE24; EIEE24; GEFSP10; HAC-2; HCN1
UniProt ID: (Human) O60741
Entrez Gene ID: (Human) 348980
nucleotide binding
ion channel activity
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
potassium channel activity
sodium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
voltage-gated cation channel activity
cAMP binding
identical protein binding
intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential
regulation of membrane depolarization
ion transport
potassium ion transport
sodium ion transport
neuronal action potential
ion transmembrane transport
cellular response to interferon-beta
sodium ion transmembrane transport
regulation of membrane potential
maternal behavior
apical protein localization
negative regulation of action potential
retinal cone cell development
protein homotetramerization
response to calcium ion
general adaptation syndrome, behavioral process
negative regulation of synaptic transmission, glutamatergic
transmembrane transport
regulation of postsynaptic membrane potential
cellular response to cAMP
potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
sodium ion import across plasma membrane
regulation of SA node cell action potential
response to L-glutamate
regulation of membrane hyperpolarization
positive regulation of membrane hyperpolarization
potassium ion import across plasma membrane
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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