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Invitrogen
HCN1 Polyclonal Antibody
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Product Details
PA5-95716
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
2.19 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein
Immunogen sequence: PSLPHEVSTL ISRPHPTVGE SLASIPQPVT AVPGTGLQAG GRSTVPQRVT LFRQMSSGAI PPNRGVPPAP PPPAAALPRE SSSVLNTDPD AEKPRFASNL
Target Information
HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCNG-1; Brain cyclic nucleotide-gated channel 1; HAC-2; Hyperpolarization-activated cation channel 2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Aliases: BCNG-1; BCNG1; C630013B14Rik; EIEE24; HAC-2; HAC2; HCN1
UniProt ID: (Human) O60741, (Mouse) O88704, (Rat) Q9JKB0
Entrez Gene ID: (Human) 348980, (Mouse) 15165, (Rat) 84390
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
potassium channel activity
cAMP binding
identical protein binding
nucleotide binding
ion channel activity
voltage-gated ion channel activity
sodium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
protein C-terminus binding
protein complex binding
ion channel
transporter
potassium ion transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
apical protein localization
retinal cone cell development
regulation of postsynaptic membrane potential
cellular response to cAMP
potassium ion transmembrane transport
regulation of membrane depolarization
transport
ion transport
sodium ion transport
negative regulation of action potential
response to calcium ion
transmembrane transport
regulation of membrane hyperpolarization
positive regulation of cation channel activity
inflammatory response
aging
cellular response to interferon-beta
maternal behavior
response to cisplatin
response to L-glutamate
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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