|Western Blot (WB)||1:300-1:2000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide from c-terminal region of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Highly expressed in pyramidal and granule layer of the hippocampus, in thalamus anterior nucleus, in the supraoptic nucleus in hypothalamus, in cerebellum, and in trapezoid nuclei and superior olivary complex in the auditory system. Detected in a subset of elongated cells in taste buds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; potassium/sodium hyperpolarization activated cyclic nucleotide-gated channel 4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Aliases: HCN4; SSS2
UniProt ID: (Human) Q9Y3Q4
Entrez Gene ID: (Human) 10021
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