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HCN4 Polyclonal Antibody
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Product Details
OSR00093W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from c-terminal region of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: HCN4.
Target Information
HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hyperpolarization activated cyclic nucleotide-gated cation channel 4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Aliases: BRGDA8; EIG18; HCN4; SSS2
UniProt ID: (Human) Q9Y3Q4
Entrez Gene ID: (Human) 10021
nucleotide binding
ion channel activity
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
potassium channel activity
sodium channel activity
protein binding
cAMP binding
identical protein binding
voltage-gated potassium channel activity involved in SA node cell action potential depolarization
regulation of heart rate
sinoatrial node development
regulation of membrane depolarization
ion transport
cation transport
potassium ion transport
sodium ion transport
muscle contraction
blood circulation
ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
transmembrane transport
regulation of cardiac muscle contraction
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
membrane depolarization during cardiac muscle cell action potential
SA node cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
sodium ion import across plasma membrane
regulation of SA node cell action potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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