This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Hcrt; Hcrt1; Hcrt2; Hypocretin; hypocretin (orexin) neuropeptide; Hypocretin-1; Hypocretin-2; Orexin; Orexin-A; Orexin-B; prepro-orexin
Gene Aliases: HCRT; NRCLP1; OX; PPORX; PPOX
UniProt ID: (Human) O43612
Entrez Gene ID: (Human) 3060