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Proteintech
HDAC1 Polyclonal Antibody
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Product Details
10197-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HDAC1 Fusion Protein Ag0256 (183-482 aa encoded by BC000301)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human HDAC1. The calculated molecular weight of HDAC1 is 55 kDa, but modified HDAC1 is about 60-65 kDa.
Immunogen sequence: VEEAFYTTD RVMTVSFHKY GEYFPGTGDL RDIGAGKGKY YAVNYPLRDG IDDESYEAIF KPVMSKVMEM FQPSAVVLQC GSDSLSGDRL GCFNLTIKGH AKCVEFVKSF NLPMLMLGGG GYTIRNVARC WTYETAVALD TEIPNELPYN DYFEYFGPDF KLHISPSNMT NQNTNEYLEK IKQRLFENLR MLPHAPGVQM QAIPEDAIPE ESGDEDEDDP DKRISICSSD KRIACEEEFS DSEEEGEGGR KNSSNFKKAK RVKTEDEKEK DPEEKKEVTE EEKTKEEKPE AKGVKEEVKL A (183-482 aa encoded by BC000301)
Target Information
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686H12203; HD1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein deacylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2
Gene Aliases: GON-10; HD1; HDAC1; Hdac1-ps; MommeD5; RPD3; RPD3L1
UniProt ID: (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4
Entrez Gene ID: (Human) 3065, (Mouse) 433759, (Rat) 297893
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
RNA polymerase II transcription factor binding
RNA polymerase II repressing transcription factor binding
RNA polymerase II transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
transcription factor binding
deacetylase activity
enzyme binding
nucleosomal DNA binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
activating transcription factor binding
histone deacetylase binding
transcription regulatory region DNA binding
protein N-terminus binding
NF-kappaB binding
repressing transcription factor binding
DNA binding
chromatin binding
transcription corepressor activity
hydrolase activity
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
protein complex binding
histone deacetylase activity (H4-K16 specific)
Krueppel-associated box domain binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
negative regulation of transcription from RNA polymerase II promoter
response to amphetamine
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein deacetylation
endoderm development
circadian rhythm
positive regulation of cell proliferation
negative regulation of cell proliferation
epidermal cell differentiation
negative regulation of gene expression
positive regulation of receptor biosynthetic process
chromatin modification
histone deacetylation
hippocampus development
neuron differentiation
positive regulation of interleukin-1 production
positive regulation of tumor necrosis factor production
circadian regulation of gene expression
cellular response to oxidative stress
odontogenesis of dentin-containing tooth
positive regulation of tyrosine phosphorylation of Stat3 protein
embryonic digit morphogenesis
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
negative regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of insulin secretion
rhythmic process
positive regulation of oligodendrocyte differentiation
negative regulation of androgen receptor signaling pathway
hair follicle placode formation
eyelid development in camera-type eye
fungiform papilla formation
histone H3 deacetylation
histone H4 deacetylation
negative regulation of canonical Wnt signaling pathway
positive regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of type B pancreatic cell apoptotic process
negative regulation of peptidyl-lysine acetylation
negative regulation of intrinsic apoptotic signaling pathway
chromatin remodeling
methylation-dependent chromatin silencing
blood coagulation
negative regulation of myotube differentiation
viral process
regulation of signal transduction by p53 class mediator
beta-catenin-TCF complex assembly
response to caffeine
response to lipopolysaccharide
response to drug
response to hyperoxia
cellular response to tumor necrosis factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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