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Product Details
24913-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HDAC10 Fusion Protein Ag18470 (320-669 aa encoded by BC125083)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TLLGDPAPP LSGPMAPCQS ALESIQSARA AQAPHWKSLQ QQDVTAVPMS PSSHSPEGRP PPLLPGGPVC KAAASAPSSL LDQPCLCPAP SVRTAVALTT PDITLVLPPD VIQQEASALR EETEAWARPH ESLAREEALT ALGKLLYLLD GMLDGQVNSG IAATPASAAA ATLDVAVRRG LSHGAQRLLC VALGQLDRPP DLAHDGRSLW LNIRGKEAAA LSMFHVSTPL PVMTGGFLSC ILGLVLPLAY GFQPDLVLVA LGPGHGLQGP HAALLAAMLR GLAGGRVLAL LEENSTPQLA GILARVLNGE APPSLGPSSV ASPEDVQALM YLRGQLEPQW KMLQCHPHLV A (320-669 aa encoded by BC125083)
Target Information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp761B039; HD10; Histone deacetylase 10; MGC149722; Polyamine deacetylase HDAC10; RP3-402G11.7
Gene Aliases: AW548891; HD10; HDAC10
UniProt ID: (Human) Q9UGX2, (Mouse) Q6P3E7, (Rat) Q569C4
Entrez Gene ID: (Human) 83933, (Mouse) 170787, (Rat) 362981
histone deacetylase activity
protein binding
enzyme binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
histone deacetylase binding
hydrolase activity
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
molecular_function
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein deacetylation
chromatin modification
histone deacetylation
negative regulation of transcription, DNA-templated
oligodendrocyte development
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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