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HDAC10 Polyclonal Antibody
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Product Details
BS-2893R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HDAC10, amino acids 561-669.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; dJ402G11.7; DKFZp761B039; HD10; HDAC10b; Histone deacetylase 10; MGC149722; Polyamine deacetylase HDAC10; related to Hda1; RP3-402G11.7
Gene Aliases: AW548891; HD10; HDAC10
UniProt ID: (Human) Q969S8, (Mouse) Q6P3E7, (Rat) Q569C4
Entrez Gene ID: (Human) 83933, (Mouse) 170787, (Rat) 362981
histone deacetylase activity
protein binding
zinc ion binding
hydrolase activity
deacetylase activity
enzyme binding
protein deacetylase activity
histone deacetylase binding
metal ion binding
acetylputrescine deacetylase activity
acetylspermidine deacetylase activity
histone deacetylase activity (H3-K14 specific)
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
molecular_function
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
protein deacetylation
chromatin modification
histone deacetylation
negative regulation of transcription, DNA-templated
DNA repair
DNA recombination
chromatin organization
autophagy
cellular response to DNA damage stimulus
macroautophagy
positive regulation of mismatch repair
reciprocal DNA recombination
macromolecule deacylation
polyamine deacetylation
spermidine deacetylation
oligodendrocyte development
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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