Sequence of this protein is as follows: MRSPPCGLLR WFGGPLLASW CRCHLRFRAF GTSAGWYRAF PAPPPLLPPA CPSPRDYRPH VSLSPFLSRP SRGGSSSSSS SRRRSPVAAV AGEPMAYSQG GGKKKVCYYY DGDIGNYYYG QGHPMKPHRI RMTHNLLLNY GLYRKMEIYR PHKATAEEMT KYHSDEYIKF LRSIRPDNMS EYSKQMQRFN VGEDCPVFDG LFEFCQLSTG GSVAGAVKLN RQQTDMAVNW AGGLHHAKKS EASGFCYVND IVLAILELLK YHQRVLYIDI DIHHGDGVEE AFYTTDRVMT VSFHKYGEYF PGTGDLRDIG AGKGKYYAVN FPMRDGIDDE SYGQIFKPII SKVMEMYQPS AVVLQCGADS LSGDRLGCFN LTVKGHAKCV EVVKTFNLPL LMLGGGGYTI RNVARCWTYE TAVALDCEIP NELPYNDYFE YFGPDFKLHI SPSNMTNQNT PEYMEKIKQR LFENLRMLPH APGVQMQAIP EDAVHEDSGD EDGEDPDKRI SIRASDKRIA CDEEFSDSED EGEGGRRNVA DHKKGAKKAR IEEDKKETED KKTDVKEEDK SKDNSGEKTD TKGTKSEQLS NP
HDAC2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
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Protein Aliases: HD2; hdac 2; hdac-2; Histone deacetylase 2; transcriptional regulator homolog RPD3; YY1-associated factor 1
Gene Aliases: HD2; HDAC2; RPD3; YAF1
UniProt ID: (Human) Q92769
Entrez Gene ID: (Human) 3066