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Proteintech
HDAC3 Polyclonal Antibody
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Product Details
10255-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HDAC3 Fusion Protein Ag0396 (187-395 aa encoded by BC000614)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC3.
Immunogen sequence: VMTVSFHKY GNYFFPGTGD MYEVGAESGR YYCLNVPLRD GIDDQSYKHL FQPVINQVVD FYQPTCIVLQ CGADSLGCDR LGCFNLSIRG HGECVEYVKS FNIPLLVLGG GGYTVRNVAR CWTYETSLLV EEAISEELPY SEYFEYFAPD FTLHPDVSTR IENQNSRQYL DQIRQTIFEN LKMLNHAPSV QIHDVPADLL TYDRTDEADA (187-395 aa encoded by BC000614)
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD3; HDAC3; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45
Gene Aliases: HD3; HDAC3; KDAC3; RPD3; RPD3-2
UniProt ID: (Human) O15379
Entrez Gene ID: (Human) 8841
transcription corepressor binding
DNA binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
hydrolase activity
deacetylase activity
enzyme binding
cyclin binding
chromatin DNA binding
protein deacetylase activity
histone deacetylase binding
GTPase binding
NF-kappaB binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
protein decrotonylase activity
histone decrotonylase activity
protein de-2-hydroxyisobutyrylase activity
protein lysine delactylase activity
ubiquitin-specific protease binding
negative regulation of transcription from RNA polymerase II promoter
establishment of mitotic spindle orientation
in utero embryonic development
positive regulation of protein phosphorylation
chromatin organization
transcription from RNA polymerase II promoter
protein deacetylation
regulation of mitotic cell cycle
epidermis development
response to xenobiotic stimulus
gene expression
negative regulation of myotube differentiation
positive regulation of protein ubiquitination
regulation of protein stability
response to nutrient levels
positive regulation of TOR signaling
negative regulation of interleukin-1 production
negative regulation of tumor necrosis factor production
circadian regulation of gene expression
protein modification process
regulation of multicellular organism growth
regulation of gene expression, epigenetic
positive regulation of protein import into nucleus
regulation of circadian rhythm
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of protein export from nucleus
rhythmic process
spindle assembly
random inactivation of X chromosome
neural precursor cell proliferation
establishment of skin barrier
cellular response to mechanical stimulus
cellular response to parathyroid hormone stimulus
cellular response to fluid shear stress
response to dexamethasone
negative regulation of ferroptosis
positive regulation of cold-induced thermogenesis
DNA repair-dependent chromatin remodeling
positive regulation of ferroptosis
cornified envelope assembly
positive regulation of type B pancreatic cell apoptotic process
negative regulation of cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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