This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-29026 targets HDAC3 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29026 immunogen is synthetic peptide corresponding to a region within amino acids 361 and 428 of Human HDAC3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HD3; Histone deacetylase 3; RPD3; RPD3-2; SMAP45
Gene Aliases: HD3; HDAC3; RPD3; RPD3-2
UniProt ID: (Human) O15379
Entrez Gene ID: (Human) 8841