Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 10 publications 10 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
ChIP assay (ChIP) |
Assay-dependent | View 1 publication 1 publication |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Published species |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
HDAC4 Fusion Protein Ag11572 (623-972 aa encoded by BC039904) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.21 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC4. The calculated molecular weight of HDAC4 is 106 kDa, but modified HDAC4 is about 140 kDa.
Immunogen sequence: SKKLLGSLA SVFVRLPCGG VGVDSDTIWN EVHSAGAARL AVGCVVELVF KVATGELKNG FAVVRPPGHH AEESTPMGFC YFNSVAVAAK LLQQRLSVSK ILIVDWDVHH GNGTQQAFYS DPSVLYMSLH RYDDGNFFPG SGAPDEVGTG PGVGFNVNMA FTGGLDPPMG DAEYLAAFRT VVMPIASEFA PDVVLVSSGF DAVEGHPTPL GGYNLSARCF GYLTKQLMGL AGGRIVLALE GGHDLTAICD ASEACVSALL GNELDPLPEK VLQQRPNANA VRSMEKVMEI HSKYWRCLQR TTSTAGRSLI EAQTCENEEA ETVTAMASLS VGVKPAEKRP DEEPMEEEPP L (623-972 aa encoded by BC039904)
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp779K1053; HD4; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0744; MITR
Gene Aliases: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288
UniProt ID: (Human) P56524
Entrez Gene ID: (Human) 9759
Molecular Function:
histone modifying enzyme
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