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Active Motif
HDAC6 Polyclonal Antibody
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Product Details
40971ACTMOTIF
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This HDAC6 antibody was raised against a synthetic peptide corresponding to amino acid residues 1-16 of human HDAC6.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Affinity chromatography
Storage buffer
PBS, pH 7.5
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
40971 is the Active Motif part number.
Target Information
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-tubulin deacetylase HDAC6; E3 ubiquitin-protein ligase HDAC6; FLJ16239; HDA6; HDAC6; histone deacetylase 5; histone deacetylase 6; histone deacetylase mHDA2; mHDA2; Protein deacetylase HDAC6; protein phosphatase 1, regulatory subunit 90; scurfy candidate 6; Tubulin-lysine deacetylase HDAC6; unnamed protein product
Gene Aliases: CPBHM; HD6; Hdac5; HDAC6; JM21; KDAC6; KIAA0901; mHDA2; PPP1R90; Sfc6
UniProt ID: (Human) Q9UBN7, (Mouse) Q9Z2V5
Entrez Gene ID: (Human) 10013, (Mouse) 15185
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription corepressor binding
actin binding
histone deacetylase activity
protein binding
beta-catenin binding
microtubule binding
zinc ion binding
transferase activity
hydrolase activity
deacetylase activity
enzyme binding
polyubiquitin binding
ubiquitin protein ligase binding
protein deacetylase activity
peroxidase inhibitor activity
ATPase inhibitor activity
histone deacetylase binding
tubulin deacetylase activity
alpha-tubulin binding
ubiquitin binding
metal ion binding
acetylspermidine deacetylase activity
tau protein binding
beta-tubulin binding
misfolded protein binding
Hsp90 protein binding
dynein complex binding
histone deacetylase activity, hydrolytic mechanism
core promoter binding
histone deacetylase activity (H3-K14 specific)
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
protein polyubiquitination
response to amphetamine
chromatin organization
protein deacetylation
ubiquitin-dependent protein catabolic process
misfolded or incompletely synthesized protein catabolic process
intracellular protein transport
autophagy
response to stress
actin filament organization
negative regulation of microtubule depolymerization
epidermal growth factor receptor signaling pathway
regulation of autophagy
positive regulation of epithelial cell migration
negative regulation of hydrogen peroxide metabolic process
regulation of mitochondrion organization
negative regulation of neuron projection development
macroautophagy
regulation of macroautophagy
axonal transport of mitochondrion
neuron differentiation
negative regulation of protein complex assembly
regulation of protein stability
protein destabilization
lysosome localization
positive regulation of protein oligomerization
regulation of microtubule-based process
protein-containing complex disassembly
positive regulation of intracellular estrogen receptor signaling pathway
cellular response to heat
response to immobilization stress
cellular response to topologically incorrect protein
aggrephagy
erythrocyte enucleation
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
negative regulation of protein complex disassembly
regulation of fat cell differentiation
negative regulation of gene expression, epigenetic
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
collateral sprouting
negative regulation of axon extension involved in axon guidance
positive regulation of dendrite morphogenesis
negative regulation of cellular component organization
positive regulation of cellular component organization
response to corticosterone
mitochondrion localization
response to misfolded protein
positive regulation of synaptic transmission, glutamatergic
cilium morphogenesis
regulation of microtubule-based movement
regulation of androgen receptor signaling pathway
dendritic spine morphogenesis
cilium disassembly
parkin-mediated mitophagy in response to mitochondrial depolarization
regulation of biological quality
regulation of establishment of protein localization
cellular response to hydrogen peroxide
regulation of microtubule cytoskeleton organization
aggresome assembly
polyubiquitinated misfolded protein transport
protein targeting to vacuole involved in autophagy
cellular response to misfolded protein
cellular response to parathyroid hormone stimulus
response to dexamethasone
tubulin deacetylation
macromolecule deacylation
polyamine deacetylation
spermidine deacetylation
membraneless organelle assembly
positive regulation of cellular response to oxidative stress
regulation of mitophagy
positive regulation of cholangiocyte proliferation
positive regulation of type 2 mitophagy
negative regulation of aggrephagy
transcription, DNA-templated
regulation of transcription, DNA-templated
response to toxic substance
positive regulation of signal transduction
response to organic substance
regulation of receptor activity
positive regulation of receptor biosynthetic process
chromatin modification
histone deacetylation
peptidyl-lysine deacetylation
regulation of gene expression, epigenetic
protein complex disassembly
Hsp90 deacetylation
response to growth factor
positive regulation of chaperone-mediated protein complex assembly
mitophagy in response to mitochondrial depolarization
positive regulation of hydrogen peroxide-mediated programmed cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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