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Applications | Tested Dilution | Publications |
---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-470 of human HDAC6 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
0.52 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2804673 |
Immunogen sequence: NEGELRVLAD TYDSVYLHPN SYSCACLASG SVLRLVDAVL GAEIRNGMAI IRPPGHHAQH SLMDGYCMFN HVAVAARYAQ QKHRIRRVLI VDWDVHHGQG TQFTFDQDPS VLYFSIHRYE QGRFWPHLKA SNWSTTGFGQ GQGYTINVPW NQVGMRDADY IAAFLHVLLP VALEFQPQLV LVAAGFDALQ GDPKGEMAAT PAGFAQLTHL LMGLAGGKLI LSLEGGYNLR ALAEGVSASL HTLLGDPCPM LESPGAPCRS AQASVSCALE ALEPFWEVLV RSTETVERDN MEEDNVEESE EEGPWEPPVL P; Cellular Location: Cell projection, Cytoplasm, Nucleus, Perikaryon, axon, dendrite
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ16239; HD6; HDA6; histone deacetylase 5; Histone deacetylase 6; Histone deacetylase mHDA2; protein phosphatase 1, regulatory subunit 90; scurfy candidate 6; Tubulin-lysine deacetylase HDAC6
Gene Aliases: CPBHM; HD6; Hdac5; HDAC6; JM21; KIAA0901; mHDA2; PPP1R90; Sfc6
UniProt ID: (Human) Q9UBN7, (Mouse) Q9Z2V5
Entrez Gene ID: (Human) 10013, (Mouse) 15185
Molecular Function:
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
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