Immunogen sequence: VLKEVYQAFN PKAVVLQLGA DTIAGDPMCS FNMTPVGIGK CLKYILQWQL ATLILGGGGY NLANTARCWT YLTGVILGKT LSSEIPDHEF
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: HD8; HDACL1; Histone deacetylase 8; histone deacetylase-like 1; MRXS6; RPD3; WTS
Gene Aliases: CDA07; CDLS5; HD8; HDAC8; HDACL1; MRXS6; RPD3; WTS
UniProt ID: (Human) Q9BY41
Entrez Gene ID: (Human) 55869