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Invitrogen
HDAC8 Polyclonal Antibody
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Product Details
PA5-87265
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human HDAC8.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HD8; Histone deacetylase 8; histone deacetylase-like 1; Protein deacetylase HDAC8; Protein decrotonylase HDAC8
Gene Aliases: 2610007D20Rik; CDA07; CDLS5; HD8; HDAC8; HDACL1; MRXS6; RGD1562895; RPD3; WTS
UniProt ID: (Human) Q9BY41, (Rat) B1WC68, (Mouse) Q8VH37
Entrez Gene ID: (Human) 55869, (Rat) 363481, (Mouse) 70315
histone deacetylase activity
protein binding
transcription factor binding
Hsp70 protein binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
metal ion binding
Hsp90 protein binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
hydrolase activity
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
transcription, DNA-templated
regulation of transcription, DNA-templated
sister chromatid cohesion
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
regulation of cohesin loading
chromatin modification
histone deacetylation
negative regulation of transcription from RNA polymerase II promoter
chromatin assembly or disassembly
negative regulation of protein ubiquitination
regulation of protein stability
regulation of telomere maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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